Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are effector lymphocytes that utilize Perforin/Granzyme B-induced apoptosis pathways to defend against virally-infected or transformed tumor cells. Cytolytic granules Perforin (PFN) and a family of serine protease including Granzyme B are secreted via exocytosis and induce apoptosis in target cells through the activation of caspases. Perforin deficient mice exhibit reduced ability to clear many viral and intracellular pathogens and are highly susceptible to B-cell lymphoma, tumors and metastases.

arigo has the most sensitive Perforin (ARG80173) and Granzyme B (ARG80171) ELISA kits in the market for the study of Perforin / Granzyme B-induced apoptosis pathways in CTLs and NK cells.

References:
Trapani and Smyth. (2002). Nat Rev Immunol 2: 735
Thiery and Lieberman. (2014). Subcell Biochem 80:197-220

Specifications

Catalog number : ARG80171

Product Name : Granzyme B ELISA Kit

Sensitivity : 8 pg/ml

ELISA Type : Sandwich ELISA

Assay Range : 15.6-1000 pg/ml

Product Description : 
Granzyme B ELISA Kit is a Enzyme Immunoassay kit for the quantification of Human Granzyme B in Serum, Plasma, Cell culture supernatants

Specifications

Catalog number : ARG80173

Product Name : Perforin ELISA Kit

Sensitivity : 20 pg/ml

ELISA Type : Sandwich ELISA

Assay Range : 39-2500 pg/ml

Product Description : 
Perforin ELISA Kit is a Enzyme Immunoassay kit for the quantification of Human Perforin in Serum, Plasma, Cell culture supernatants