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公司名称:伟德官网地址-bv伟德体育app-betvlctor伟德app下载 - betvlctor伟德app下载伟德官网地址bv伟德体育app有限公司

地址:betvlctor伟德app下载省长沙市天心区解放西路466号汇源大厦1805室

电话:0731-84321919

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Immunosuppressive role of HMGB1 in TME

HMGB1 is a multifunctional protein with various roles in different cellular compartments. It exhibits a dual role in cancer cells; the intracellular HMGB1 acts as an anti-tumor protein stabilizing the genome, whereas the chronic released HMGB1 behaves as a pro-tumor protein with immunosuppressive functions.

In tumor microenvironment (TME), tumor cell-secreted HMGB1 inhibits the activities of T cells by inhibiting the maturation of dendritic cells (DCs) and promoting the activities of myeloid-derived suppressor cells (MDSCs) and Treg. HMGB1 also inhibits anti-tumor activity by binding to the immunosuppressive receptor TIM‐3. Moreover, HMGB1 interacts with RAGE and induces tumor cell migration, invasion and metastasis.

HMGB1 is a potential prognosis marker and a target for cancer therapy.  arigo offers quality antibodies and ELISA kits to facilitate the research of the detailed mechanism underlying the immune suppression by HMGB1.
 

HMGB1 ELISA kits and antibodies

 
Reactivity: Hu
Sensitivity: 0.3 ng/ml
Sample: Plasma, cell culture sup.
 
 
Reactivity: Ms, Rat
Sensitivity: 0.3 ng/ml
Sample: Plasma, cell culture sup., lysates
 
 
Reactivity: Hu, Ms, Rat
Sensitivity: 0.15 ng/ml
Sample: Serum

 
 

 

Antibodies for MDSCs

 

Cat. No.
Product
Clonality
Reactivity
Application
ARG65463
Mouse mAb
Hu, NHuPrm
FACS, FuncSt, ICC/IF, IHC-Fr, IP
ARG54260
Mouse mAb
Hu, NHuPrm
FACS, ICC/IF, IHC-Fr
ARG22000
Rat mAb
Hu, Ms, Bb, Mk
BL, FACS, ICC/IF, IHC-Fr, IHC-P, IP
ARG65478
Rat mAb
Hu, Ms, Bb, Mk
FACS
ARG20843
Rat mAb
Ms
FACS, ICC/IF
ARG65560
Mouse mAb
Hu, NHuPrm
FACS, FuncSt, ICC/IF, IHC-Fr, IP, WB
ARG22104
Rat mAb
Ms
Depletion, FACS, IHC-Fr, IHC-P, IP

 

Antibodies for DCs

Cat. No.
Product
Clonality
Reactivity
Application
ARG21322
Mouse mAb
Hu, Mk
BL, FACS, IHC-Fr, IP
ARG23522
Hamster mAb
Ms
FACS, ICC/IF, IHC-Fr, IP
ARG23079
Mouse mAb
Hu, Rb
FACS, IHC-Fr, IHC-P

 

Antibodies for TAMs

 

Cat. No.
Product
Clonality
Reactivity
Application
ARG55553
Rat mAb
Hu, Ms
FACS, IHC-Fr, WB
ARG53010
Rabbit mAb
Hu, Ms
IHC-Fr, IHC-P, WB
ARG22838
Mouse mAb
Hu, Bo, Gpig, Pig, Mk, Sh
ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB
ARG56138
Rabbit pAb
Hu, Ms, Rat
FACS, IHC-P, WB
ARG55554
Mouse mAb
Hu, Ms
FACS, FuncSt, ICC/IF, IHC-Fr, IP, WB
ARG22456
Rat mAb
Ms
FACS, ICC/IF, IHC-Fr, IP
ARG22372
Rabbit pAb
Hu, Ms, Rat, Pig
ICC/IF, IHC-P, WB

 

Antibodies for Treg

 

Cat. No.
Product
Clonality
Reactivity
Application
ARG21295
Mouse mAb
Hu
FACS, ICC/IF, IHC-Fr, WB
ARG21979
Rat mAb
Ms
BL, Depletion, FACS, ICC/IF, IHC-Fr, IP
ARG65448
Rat mAb
Ms
FACS, ICC/IF, IHC-Fr
ARG65860
Rabbit mAb
Hu
FACS, IHC-P, IP, WB
ARG54202
Mouse mAb
Hu, Ms
FACS, WB
ARG53050
Rabbit mAb
Hu
IHC-P

 

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